Name: Xiaoyi Chen Position：Professor of Pathology E-mail：xychen@gdmc.edu.cn

Research Fields：
Etiology and Pathogenesis of Nasopharyngeal carcinoma
Telomerase and Tumors

Published Papers:
1. Chen, X., Ghosh, A., Moore, M. and Arrand, J.R. 1991. Epstein-Barr
virus cytotoxic response to autologous fibroblasts expressing antigens
LMP and EBNA2 in recombinant vaccinia viruses. Chinese Journal of
Virology, 1991; 7(2):125-131.

2. Chen, X. (1991). Establishment of EBV specific T cell clones and
their response to the recombinant IL2 in different concentration. Acta
Academiae Medicinae Zhanjiang, 9:8-11.

3. Littler, E., Baylis, S.A., Connolly, Y., Conway, M.J., Mackett, M.,
Chen, X., Zeng, Y. and Arrand, J.R. (1991). Diagnosis of
nasopharyngeal carcinoma using the Epstein-Barr virus coded alkaline
DNase, membrane antigen and thymidine kinase. In: Epstein-Barr Virus
and Human Disease 1990. Humana Press, Clifton, New Jersey, pp. 353-356.

4. Chen, X. (1992). EBV specific T cell cytotoxicity effected by CD3
antibody. Chinese Journal of Microbiology and Immunology,
12(3):189-191.

5. Chen, X., Pepper, S. deV. and Arrand, J.R. (1992). Prevalence of
the A- and B-types of Epstein-Barr virus DNA in nasopharyngeal carcinoma
biopsies from Southern China. J. Gen. Virol., 73:463-466.

6. Chen, X. and Cai, Y. (1994). The expression of HLA, Epstein-Barr
virus nuclear antigen and the infiltration of T lymphocyte subsets in
nasopharyngeal biopsy tissues. Chinese Journal of Otorhinolaryngology,
29(1):6-9.

7. Chen, X., Sun, N. and J.R. Arrand. (1994). Investigation of EBV
DNA BamHI fragment, EBNA-2 types and EBNA expression in benign and
malignant nasopharyngeal biopsies. Chinese Journal of Pathology,
73:200-203.

8. Sun, N. and Chen, X. (1995) The value of polymerase chain reaction
on Epstein-Barr virus subtypes in the differentiation of benign and
malignant nasopharyngeal biopsies. Chinese Journal of
Otorhinolaryngology. 30 (4): 213-215.

9. Sun, N. and Chen, X. (1995) Transfection and morphological changes
of human embryo nasopharyngeal epithelial cells infected by
Epstein-Barr virus synergized with TPA in vitro. Chinese Journal of
Oncology, 17:15-18.

10. Sun, N. and Chen, X. (1995) Observation of IgA against recombinant
EBV thymidine kinase in sera of patients with nasopharyngeal carcinoma.
Journal of Current Oncology, 2:102-104.

11. Sun, N. and Chen, X. (1996) EB virus detection by PCR in
experimental carcinogenesis of human nasopharyngeal epithelia
transplanted into nude mice. Journal of Guangdong Medical College,
14:101-102.

12. Sun, N. and Chen, X. (1996) Changes of HLA phenotypes induced by
Epstein-Barr virus infection on human nasopharyngeal epithelia. Chinese
Journal of Microbiology and Immunology, 16 (5): 374-376.

13. Chen, X. and Sun, N ( 1996) Detection of Epstein-Barr virus and
EBNA2 subtypes in biopsies of nasopharyngeal carcinoma and
Non-Hodgkin's lymphoma. Chinese Journal of Clinical and Experimental
Pathology, 12:13-14.

14. Sun, N. and Chen, X. (1998) The transfection and morphological
changes of human embryonic nasopharyngeal epithelia infected by
Epstein-Barr virus in cooperation with promoter in vitro and in vivo.
Chinese J Exp Clin Virol, 12:70-73

15. Zhang, Q, Sun, N. and Chen, X. (1998) Effects of EB Virus LMP1 on
the Growth and HLA Expression of Human Nasopharyngeal Carcinoma Cell
Line CNE1. Chinese Journal of Microbiology and Immunology. 18(3):235

16. Zhang, Q, Sun, N. and Chen, X.( 1998) Effect of EBV-LMP on Proliferation of NPC Cell Line CNE1 in vitro. Journal of Guangdong Medical College,16(1-2):19

17. Zhang, Q, Sun, N. and Chen, X.( 1998) Effect of EB Virus LMP and DMSO on the Differentiation, Growth of Human Nasopharyngeal Carcinoma Cell in vitro. Chinese Journal of Clinical and Experimental Pathology, 14(5):488.

18. Zhang, Q, Sun, N. and Chen, X. ( 1999) Effect of EBV-LMP on Proliferation of Nasopharyngeal Carcinoma Cell Line CNE1. Cancer Research on Prevention and Treatment. 26（2）：84

19. Zhang, Q, Sun, N. and Chen, X. ( 1999) Effect of EB Virus LMP on the fifferentiation and Growth of Human Nasopharyngeal Carcinoma Cell Line CNE1. Chinese J. of Pathology. 28（4）285

20. Zhang, Q, Sun, N. and Chen, X. ( 1999) Morphological Quantitative Study on Human Nasopharyngeal Carcinoma Cell Line CNE1 Transfected With EB Virus LMP Gene. Tumor. 19（2）84

21． Li Yansong, Chen Xiaoyi et al.(1999) The Effect of EB Virus infection on the Changes of Cellular Morphometric and DNA Content of NPC Cell Line in vitro. Journal of Guangdong Medical College. 17（4）：313

22. Zhao Yinghai, Chen Xiaoyi et al. (2000) Effects of anticancer drug DDP on Telomerase Activity in the Cell Lines of Nasopharyngeal Carcinoma. Chinese Journal of Cell Biology.

23. The Effect of Epstein-Barr Virus Infection on the Activities of Protein Kinase C and Tyrosine Protein Kinase in Different Subcellular Fractions of CNE-2Z Cell Line in vitro. Chinese Journal of Cell Biology. 2000:22（2）：90-94

24. Heterogeneity of HLA and EBER Expression in Epstein-Barr Virus-Associated
Nasopharyngeal Carcinoma. Int.J.Cancer . 2000:88, 949-955

25. Change of Telomerase Activity in Human Benign Breast Lesions and Breast Cancers. Journal of Guangdong Medical College，2000，18（1）：7-8

26. Construction of an Expression System of Epstein-Barr Virus Thymidine Kinase(TK). Journal of Guangdong Medical College，2001，19（1）：4 - 6

27．Expression of Thymidine Kinase for Epstein-Barr Virus in E.Coli. Chinese Journal of Histochemistry and Cytochemistry，2001，10（3）：263 - 265

28．Relationship between expression of bcl-2, P53,c-erbB-2 and EB Virus LMP1 in Human
Nasopharyngeal Carcinoma Cell Progressing in Nude Mice.J. Practical Oncology，
2001，16（6）：374

29. Antibodies to Epstein-Barr Virus Thymidine Kinase: A Characteristic Marker for the
Serological Detection of Nasopharyngeal Carcinoma. Int.J.Cancer . 2001，91：692-697

30. Chen Yan, Chen Xiaoyi.( 2002) The Effect of Epstein-Barr Virus LMP1 on Apoptosis of Nasopharyngeal Carcinoma Cell Line CNE1. Cancer. 21（5）：498-503

Supervision of Master's Degree Students:

1. Li Yansong (1995) The effect of EBV transfection in vitro on the
changes of growth, differentiation and signal transduction pathways of
nasopharyngeal carcinoma cell lines.

2. Zhang Qinming (1997) The effect of EB virus LMP on the
differentiation, growth and HLA expression of nasopharyngeal carcinoma
cell line CNE-1.

3. Chen Yan(1998) The Effect of EB Virus LMP1 on Growth Characteristics of
Nasopharyngeal Carcinoma Cell Line CNE1 and the Study of the Related Mechanism.

4. Zhao Yinghai(1999) Studies on the Expression of Telomerase in Malignant Tumors and Apoptosis in NPC Cell Lines Induced by DDP and a Telomerase Ribozyme

5. Guo Xinming (1999) The Effect of EB Virus LMP1 on MMP2,MMP9 of Nasopharyngeal Carcinoma Cell

6. Liu Biao (2000) The Effect of EB Vruse LMP1 on the Cell Cycle of Nasopharyngeal Carcinoma Cell Lines

7. Zuo Rong (2001)

Examiner of Master's Degree Students:

1. Huang Peichun (1990) Reactions of Epstein Barr virus infected
peripheral blood mononuclear cells and effects of suppressor T
lymphocytes induced by its antigen on the process in nasopharyngeal
carcinoma patients and various titers of IgA/VCA antibody individuals.

2. Huang Tianyou ( 1990) The studies of the induction and the effect
of non-specific immunoregulatory T lymphocytes in the nasopharyngeal
carcinoma patients and Epstein- Barr virus seropositive individuals.

3. Zhang Li (1992) Changes and effects of Epstein-Barr virus-induced
IL-2, TNF, IFN and supernantants in the nasopharyngeal carcinoma
patients and IgA/VCA positive individuals.

4. Chai Huaqi (1993) Cytostatic effect and cause on tumor cells of
supernant of PBMC induced by EBV-Ag in EBV seropositive individuals.

5. Yao Yunhong (1994) A study of the relationship between adhesion,
invasion, growth properties, angiogenesis and the metastatic capacity
of mucous gastric carcinoma cell line (MGc80-3) and its clone strains.

6. Luo Minghua (1997) The establishment of orthotopic implantation
model of human gastric carcinoma in nude mice and the study of its
metastatic behavior.

7. Luo Huijun (1997) Study on the Effect of Epstein-Barr Virus Latent Membrane Protein 1
on Proliferation of Human Nasopharyngeal Carcinoma Cell Line CNE-1 and its Mechanisms

8. Yuan Huozhong (1997) Effect of L-Arginine on Mononuclear Phagocyte System Phagocytic Function and Hepatocyte Energy Metabolism in the Rat with Obstructive Jaundice

9. Jiang Hanguo (1998) Detection of Abnormal Multiple Genetic Expression in the Progression of Gastric Adenocarcinoma

10. Jiang Juhong(1998) Heterogeneity of in vitro Radiosensitivity in Nasopharyngeal Carcinoma Cells and Radisensitization of Radioresistant Subline

Department of pathology